Demographics and clinical manifestations of patients with Raoultella terrigena infections: A Retrospective Single Center Study from Karachi, Pakistan

Ishfaque Ahmed; Nosheen Nasir; Fizza Farooqui; Faisal Mahmood

doi:10.61529/idjp.v33i3.284

Authors

Ishfaque Ahmed Sindh Infectious Diseases Hospital and Research Centre, Karachi Pakistan
Nosheen Nasir Aga Khan University Hospital, Karachi Pakistan https://orcid.org/0000-0003-1610-8748
Fizza Farooqui Sindh Infectious Diseases Hospital and Research Centre, Karachi Pakistan https://orcid.org/0000-0001-5016-6701
Faisal Mahmood Aga Khan University Hospital, Karachi Pakistan https://orcid.org/0000-0002-3390-7659

DOI:

https://doi.org/10.61529/idjp.v33i3.284

Abstract

Background: Raoultella terrigena (formerly Klebsiella terrigena) is an environmental gram-negative rod. It can cause infections in humans, especially in immunosuppressed patients and tends to be multi-drug resistant, limiting treatment options. There is lack of data on clinical presentation and outcomes of infections due to this organism. In this study; we describe the clinical features (presenting complaints, co-morbid diseases, complications, etc.), available treatment options, and outcomes (hospital/ICU stay, mortality) of patients with R. terrigena infections, seen retrospectively over six years.

Material and Methods: A cross-sectional study was conducted on all adult hospitalized patients with clinical specimens positive for Raoultella terrigena at a 700-bedded tertiary care hospital in Karachi, Pakistan, from January 2013 to December 2018.

Results: We identified 58 patients with R. terrigena isolated from different cultures specimens, of which n=12 (22.6%) were colonizers. The median age was 61.5 years (IQR=43-71), and most were male (n=28). The most common site of infection was the respiratory tract in 28.3%, then urinary tract in 26%, and central line in 26.1%. Amongst infected cases, 37% had septic shock, 45.7% had respiratory failure.

Conclusion: R. terrigena is a multi-drug-resistant organism with a high mortality rate and can cause hospital-acquired respiratory tract infections in patients.

Keywords: Raoultella terrigena, Klebsiella terrigena, Raoultella species, Klebsiella species.

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