Reversal of graft dysfunction following treatment of urinary tract infections in renal transplant recipients
DOI:
https://doi.org/10.61529/idjp.v35i2.527Abstract
Background: UTI is one of the most common complications of the renal transplant recipients. The aim of the study is to assess the reversal of graft malfunction following the management of urinary tract infection in kidney transplant patients.
Material and Methods: This was a prospective observational cohort study done at the Department of Transplant Nephrology, Sindh Institute of Urology and Transplantation. Non-probability consecutive sampling was used to select a total of 70 renal transplant recipients aged between 18 - 65 years with UTI and graft dysfunction. Graft dysfunction reversal was measured at 6 weeks of antibiotic treatment and was divided into complete, partial, and no reversal. The analysis of data was performed by SPSS 22.0 with p<0.05 as significant value.
Results: Graft dysfunction reversal was complete in 38 out of 70 patients (54.3%), partial in 20 out of 70 (28.6%), and absent in 12 out of 70 (17.1%). On multivariable logistic regression analysis, diabetes mellitus (AOR = 0.38, p = 0.041), hypertension (AOR = 0.42, p = 0.048), high baseline creatinine ≥2 mg/dL (AOR = 0.31, p = 0.023), and infection with multidrug-resistant organisms (AOR = 0.56, p = 0.019) were independently associated with decreased odds of complete reversal. The most frequent pathogens were Escherichia coli (32/70, 45.7%) and Klebsiella pneumoniae (18/70, 25.7%).
Conclusions: Graft dysfunction related to UTI is reversible in a high percentage of renal transplant recipients. Comorbidities, impaired baseline renal, and multidrug-resistant infections have a negative impact on recovery.
Keywords: Creatinine; Drug Resistance, Graft Dysfunction, Kidney Transplantation.
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Copyright (c) 2026 Dr Mehak Abro, Prof. Ejaz Ahmed, Dr Ranjeet Kumar, Dr Imran Ali, Dr Sidra German, Dr Huda Narejo
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