Unraveling the mosaic of emerging nosocomial infections: Revealing insights from two cases of Ochrobactrum anthropi bacteremia
DOI:
https://doi.org/10.61529/idjp.v34i1.346Abstract
Ochrobactrum anthropi with its strong survival ability and subtle clinical presentation, has been associated with hospital-acquired infections in immunocompromised patients. Lack of knowledge regarding its clinical importance is the prime reason for underreporting of cases. We present here two cases of Ochrobactrum anthropi bacteremia in nephrology and oncology patients, suggesting that these infections may be fairly common in immunocompromised individuals. No antimicrobial resistance was observed in our first case and the patient responded to monotherapy with meropenem whereas, the second case involved infection with a multidrug resistant strain of Ochrobactrum anthropi and improved with combination therapy comprising of levofloxacin and trimethoprim-sulfamethoxazole. To ensure that such pathogens are not missed, more thorough and accurate diagnostic procedures must be employed. A favorable outcome in such cases can be possible with prompt identification and optimal antibiotic therapy.
Keywords: Ochrobactrum anthropi, Nephrology, Oncology, Immunocompromised, Bacteremia
References
Khan D, Mukherjee T, Gupta S. Ochrobactrum anthropi sepsis in intensive tertiary care. J Basic Clin Med. 2014; 3(01): 18–20. DOI: https://doi.org/10.7759/cureus.59123
CLSI Performance Standards for Antimicrobial Susceptibility Testing 33rd ed. CLSI supplement M100. Clinical and Laboratory Standards Institute; 2023. Avaible from: https://iacld.com/UpFiles/Documents/672 a1c7c-d4ad-404e-b10e-97c19e21cdce.pdf
Aguilera-Arreola MG, Ostria-Hernández ML, Albarrán-Fernández E, Juárez-Enriquez SR, Majalca-Martínez C, Rico-Verdín B, et al. Correct identification of Ochrobactrum anthropi from blood culture using 16rRNA sequencing: A first case report in an immunocompromised patient in Mexico. Front Med (Lausanne). 2018; 5: 205. DOI: https://doi.org/10.3389/fmed.2018.00205
Kassab I, Sarsam N, Affas S, Ayas M, Baang JH. A case of Ochrobactrum intermedium bacteremia secondary to cholangitis with a literature review. Cureus. 2021; 13(4): e14648. DOI: https://doi.org/10.7759/cureus.14648
Ryan MP, Pembroke JT. The genus Ochrobactrum as major opportunistic pathogens. Microorganisms. 2020; 8(11): 1797. DOI: https://doi.org/10.3390/microorganisms8111797
Rastogi N, Mathur P. Ochrobactrum anthropi: An emerging pathogen causing meningitis with sepsis in a neurotrauma patient. J Infect Dev Ctries. 2017; 11(9): 733–5. DOI: http://dx.doi.org/10.3855/jidc.9146
Thoma B, Straube E, Scholz HC, Al Dahouk S, Zöller L, Pfeffer M, et al. Identification and antimicrobial susceptibilities of Ochrobactrum spp. Int J Med Microbiol. 2009; 299(3): 209–20.
DOI: http://dx.doi.org/10.1016/j.ijmm.2008.06.009
Zhu M, Zhao X, Zhu Q, Zhang Z, Dai Y, Chen L, et al. Clinical characteristics of patients with Ochrobactrum anthropi bloodstream infection in a Chinese tertiary-care hospital: A 7-year study. J Infect Public Health. 2018; 11(6): 873–7. DOI: http://dx.doi.org/10.1016/j.jiph.2018.07.009
Mahmood MS, Sarwari AR, Khan MA, Sophie Z, Khan E, Sami S. Infective endocarditis and septic embolization with Ochrobactrum anthropi: Case report and review of literature. J Infect. 2000; 40(3): 287–90. DOI: http://dx.doi.org/10.1053/jinf.2000.0644
Aravinda A, Ranjeeta A, Venkatesh BM, Bhaskar BH. Two case reports of Ochrobactrum anthropi bacteremia: An overlooked pathogen. J Lab Physicians. 2023; 15(1): 166–8. DOI: http://dx.doi.org/10.1055/s-0042-1757235
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Copyright (c) 2025 Moiz Khan, Nazia Khursheed, Fareeha Adnan, Qurat-ul-Ain Zahid
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