In Vitro Activity of Ceftaroline against Methicillin-Resistant Staphylococcus Species

Abstract

Objectives: To determine the in vitro susceptibility of Ceftaroline against Methicillin-resistant Staphylococcus species.
Methodology: This observational study was conducted at the Department of Microbiology, Ziauddin University Hospital, Karachi, from July 2014 to March 2015. Consecutive clinical isolates of Staphylococcus species were collected and identified by conventional microbiological techniques. Antimicrobial susceptibility testing was carried out by Kirby-Bauer disc diffusion method. The results were interpreted by using Clinical Laboratory Standard Institute criteria. Methicillin resistance was detected by using Cefoxitin disk as a surrogate marker. Statistical analysis was performed by Statistical Package for the Social Sciences version-17.

Results: A total of 276 clinical isolates of Methicillin- Resistant Staphylococci were obtained during the study period. In these
276 isolates, 103 (37.3%) were Methicillin-Resistant Staphylococcus aureus, and 173 (62.7%) were Methicillin resistant Coagulase negative Staphylococci. All 276 (100%) isolates of Methicillin- Resistant Staphylococci were sensitive to Ceftaroline.
Conclusion: Ceftaroline exhibited potent antimicrobial activity against Methicillin- Resistant Staphylococci isolates including
Methicillin-Resistant Staphylococcus aureus. Ceftaroline is equally effective as other options for treating Methicillin-Resistant Staphylococci isolates.
Key words: In vitro susceptibility. Ceftaroline. Methicillin-resistant. Staphylococcus species.